SMB Faculty Profiles

Jean Celli

Jean Celli

Associate Professor

jean.celli@wsu.edu

Office
Phone: 509-335-4040

Departments

  • WSU Paul G. Allen School for Global Animal Health (primary appointment)
  • School of Molecular Biosciences, WSU (affiliate faculty)
  • Department of Veterinary Microbiology and Pathology, WSU (affiliate faculty)

Affiliated Organizations

  • American Society of Microbiology (ASM)
  • American Association for the Advancement of Science (AAAS)

 

Biography

Dr. Celli obtained his PhD from the Université Pierre & Marie Curie, Paris 6, France in 1997. His thesis focused on genetic mobile elements that transfer antibiotic resistance among pathogenic bacteria. He moved in 1998 to Vancouver, Canada, for a postdoctoral position in bacterial pathogenesis in the laboratory of Dr. B. Brett Finlay at the University of British Columbia, where he studied how Enteropathogenic Escherichia coli (EPEC) prevents its uptake by immune phagocytes. In 2001, he obtained an INSERM Research scientist position and joined the group of Dr. Jean-Pierre Gorvel at the Centre d’Immunologie de Marseille-Luminy, France, where he started studying the intracellular cycle of the zoonotic bacterial pathogen Brucella abortus. In 2004, he obtained an NIH investigator position at the Rocky Mountain Laboratories, NIAID in Montana, where he continued his studies of bacterial pathogen interactions with phagocytes, focusing on Brucella abortus and Francisella tularensis. Dr. Celli was recruited to the WSU Paul G. Allen School for Global Animal Health as an Associate Professor in July 2013, to further pursue his research on the pathogenesis of zoonotic bacteria.

Personal Statement

I grew up in the suburbs of Paris, wandering through some rebel teenage years, when my high school biology teacher managed to trigger my interest for the scientific method in biology, and ultimately convinced me to take the path I am still walking today. My fascination for the bacterial world came from summer internships in some dark basements of the Pasteur Institute as an undergraduate student, and subsequent brighter training experiences in bacterial genetics during my PhD. Drawn into the field of bacterial pathogenesis, I moved to Canada for some postdoctoral training in the laboratory of Dr. B. Brett Finlay in Vancouver, which cemented my admiration and curiosity for pathogenic microbes and how they exploit host cell functions to cause disease. After a couple of transatlantic moves and additional training that further focused my interests, I finally settled in the US to develop a research career on the pathogenesis of zoonotic intracellular bacteria. 

Although I grew up in an urban environment, my travels and most recent workplaces have opened me to the wonders of the outdoors. When not at work, I often escape mountain biking and hiking in some wilder places. 

Education and Training

  • BSc - Université Paris 11
  • PhD - Université Pierre & Marie Curie, Paris 6
  • Postdoctoral training at the University of British Columbia
List of Publications

Select Publications

  • Miller CN, Smith EP, Cundiff JA, Knodler LA, Bailey Blackburn J, Lupashin V, Celli J. (2017) A Brucella Type IV Effector Targets the COG Tethering Complex to Remodel Host Secretory Traffic and Promote Intracellular Replication. Cell Host Microbe 22(3):317-329.e7. doi: 10.1016/j.chom.2017.07.017. Epub 2017 Aug 24. PMID: 28844886 PMCID: PMC5599354
  • Smith EP, Miller CN, Child R, Cundiff JA, Celli J. (2016) Postreplication Roles of the Brucella VirB Type IV Secretion System Uncovered via Conditional Expression of the VirB11 ATPase. mBio. 7(6). pii: e01730-16. doi: 10.1128 PMID: 27899503 PMCID: PMC5137499
  • Case ED, Chong A, Wehrly TD, Hansen B, Child R, Hwang S, Virgin HW, Celli J. (2014) The Francisella O-antigen mediates survival in the macrophage cytosol via autophagy avoidance. Cell Microbiol. 16(6):862-77 PMID: 24286610 PMCID: PMC4028363
  • Starr T, Child R, Wehrly TD, Hansen B, Hwang S, López-Otin C, Virgin HW, Celli J. (2012) Selective subversion of autophagy complexes facilitates completion of the Brucella intracellular cycle. Cell Host Microbe. 11(1):33-45 PMID: 22264511 PMCID: PMC3266535
  • Celli J, de Chastellier C, Franchini DM, Pizarro-Cerda J, Moreno E, Gorvel JP. (2003) Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum. J Exp Med. 198(4):545-56. PMID: 12925673 PMCID: PMC2194179

 

Washington State University