Microbial Genetics

MBioS 426

Course Instructors:

Mike Kahn, 509-335-8327, Clark 203

Class Information:

Syllabus

Lectures:

L = lecture; D = discussion; H=holiday;

PDF files corresponding to the papers are available below using your WSU Network ID and password.

When logging in with your NID and password, please prefix your NID with "AD\". It should look like the following:

Login: AD\"your WSU NID"
Password: "your NID password"

The site is best accessed using Windows Internet Explorer. More information about the papers can be found in the “MBioS426 Web Documents” section.

*Exam dates are sometimes adjusted by a day to reduce conflicts with other courses. Please let me know of conflicts as you become aware of them.

L1	Jan 8	Introduction to the course; Some history, some lies
L2	Jan 10	The scientific paper (Perry, Pirsig, Gopen & Swan)
D1	Jan 12	Avery et al.; Dawes; Meselson & Stahl; Hanawalt; Davis
H	Jan 15	MLK Holiday
L3	Jan 17	DNA and DNA replication
L4	Jan 19	DNA replication: Systems of study—models and mutants
D2	Jan 22	Okazaki et al.; Amado & Kuzminov
L5	Jan 24	DNA replication: Enzymes and in vitro replication
L6	Jan 26	DNA replication: Systems of study--small replicons
D3	Jan 29	Brutlag et al.; Wickner et al.; Schekman et al.
L7	Jan 31	DNA replication: Control
L8	Feb 2	Recombinant DNA: Basic manipulations
D4	Feb 5	Hwang & Kornberg; Boye & Løbner-Olesen;Katayama
L9	Feb 7	Recombinant DNA: Basic manipulations
Exam 1	Feb 8 7:00-8:30PM	Includes material through Feb 5.
D5	Feb 9	Murdock et al.; Uchiyama et al.; Ellington & Szostak
L10	Feb 12	Gene exchange: Generalized
L11	Feb 14	Gene exchange: Specialized
D6	Feb 16	Heinemann & Sprague; Waldor & Mekalanos; Thomas and Nielsen
H	Feb 19	President's Day
L12	Feb 21	Homologous recombination
L13	Feb 23	Insertion sequences and transposons
D7	Feb 26	Kleckner et al.
L14	Feb 28	Mutations and mutagenesis
L15	Mar 2	DNA Repair
D8	Mar 5	Kenyon & Walker; LeClerc et al., Horst et al.
L16	Mar 7	RNA synthesis and protein synthesis
Exam 2	Mar 8 7:00-8:30PM	Includes material through Mar 5.
L17	Mar 9	Regulation of gene expression: repression and activation
Spring Break	Mar 12-16
D9	Mar 19	Huang et al.; Noller et al.; Bell & Lewis
L18	Mar 21	Regulation of gene expression: termination
L19	Mar 23	Regulation of gene expression: other mechanisms
D10	Mar 26	Oxender et al.; Epshtein et al.; Yanofsky
L20	Mar 28	Regulation of gene expression: other mechanisms
L21	Mar 30	Regulation of gene expression: other mechanisms
D11	Apr 2	Ronson et al.; Utsumi et al., Losick & Shapiro; Hughes et al.
L22	Apr 4	Plasmids in nature
Exam 3	Apr 5 7:00-8:30PM	Includes material through Apr 2.
L23	Apr 6	Antibiotic resistance
D12	Apr 9	Thomas; Hughes & Datta; Wegener et al.; Talbot et al.
L24	Apr 11	Evolution of microorganisms
L25	Apr 13	Some horizons in genetic manipulation of microbes
D13	Apr 16	Olson & Woese; Urwin and Maiden; Kellis et al.
L26	Apr 18	Genomics of microbial systems
L27	Apr 20	Genomics of microbial systems
D14	Apr 23	Rosamond and Alsop; Raoult et al.; Boulos et al.; Rajan
L28	Apr 25	A future
L29	Apr 27	A past
Final	May 1 3:10PM