Xun, Luying
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Research Interests
Prof. Xun is interested in how microorganisms interact with environmental factors, including pollutants and redox changes. One research area is on the biochemistry of microbial degradation and biotransformation of xenobiotics. He, co-workers, and collaborators have elucidated the complete metabolic pathways for the degradation of 2,4,5-trichlorophenoxyacetic acid, pentachlorophenol, 2,4,6-trichlorophenol, ethylenediaminetetraacetic acid (EDTA), and nitrilotriacetic acid. Another area is on how Escherichia coli senses and responds to redox changes.

Publications (2000-Current)
Bohuslavek1, J., S. Chanama, R. L. Crawford, and L. Xun. 2005. Identification and Characterization of Hydroxyquinone Hydratase Activities from Sphingobium chlorophenolicum ATCC 39723. Biodegradation. 16:353-362.

Puzon, G. J., Roberts, A. G, Kramer, D. M, and Xun, L. 2005. Formation of soluble organo-chromium(III) complexes after chromate reduction in the presence of cellular organics. Environ. Sci. Technol. 39:2811-2817

Xun, L., and C. M. Webster. 2004. A monooxygenase catalyzes sequential dechlorinations of 2,4,6-trichlorophenol by oxidative and hydrolytic reactions. J. Biol. Chem. 279:6696-6700.

Gisi, M. R. and L. Xun. 2003. Characterization of chlorophenol 4-Monooxygenase (TftD) and NADH:FAD oxidoreductase (TftC) of Burkholderia cepacia AC1100. J. Bacteriol. 185:2786-2792.

Louie, T. M., X. S. Xie, and L. Xun. 2003. Coordinated production and utilization of FADH 2 by NAD(P)H-flavin oxidoreductase and 4-hydroxyphenylacetate 3-monooxygenase. Biochemistry 42:7509-7517.

Yang, H., G. Luo, P. Karnchanaphanurach, T. M. Louie, L. Xun, and X. S. Xie. 2003. Protein conformational dynamics probed by single-molecule electron transfer. Science 302:262-266.

Liu Y, Y. Liu, Y. Dai, L. Xun, and M. Hu. 2003. Enteric disposition and recycling of flavonoids and ginkgo flavonoids. J. Altern. Complement. Med. 9:631-40.

ouie, T. M., C. M. Webster, and L. Xun. 2002. Genetic and biochemical characterization of a novel 2,4,6-trichlorophenol degradation pathway in Ralstonia eutropha JMP134. J. Bacteriol. 184:3492-3500.

Puzon, G. J., J. N. Petersen, A. G. Roberts, D. M. Kramer, and L. Xun. 2002. A bacterial flavin reductase system reduces chromate to a soluble chromium(III)-NAD+ complex. Biochem. Biophys. Res. Comm. 294:76-81.

Cai, M, and L. Xun. 2002. Organization and regulation of pentachlorophenol-degrading genes in Sphingobium chlorophenolicum ATCC 39723. J. Bacteriol. 184:4672-4680.

Louie, T. M., H. Yang, P. Karnchanaphanurach, X. S. Xie, and L. Xun. 2002. FAD is a preferred substrate and an inhibitor of Escherichia coli general NAD(P)H:flavin oxidoreductase. J. Biol. Chem. 277: 39450-39455.

Bohuslavek, J., J. Payne, Y. Liu, H. Bolton, Jr., and L. Xun. 2001. Cloning, sequencing and characterization of a gene cluster involved in EDTA degradation from the bacterium BNC1. Appl. Environ. Microbiol. 67:688-695.

Liu, Y., T. M. Louie, J. Payne, J. Bohuslavek, H. Bolton, Jr., and L. Xun. 2001. Identification, purification and characterization of iminodiacetate oxidase from the EDTA-degrading bacterium BNC1. Appl. Environ. Microbiol. 67:696-701.

Vanbriesen, J. M., B. E. Bittmann, L. Xun, D. C. Girvin, and H. Bolton, Jr. 2000. The rate-controlling substrate of nitrilotriacetate for biodegradation by Chelatobacter heintzii. Environ. Sci. Technol. 34:3346-3353.