Pall, Martin L.
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Research Interests
Dr. Pall has long-term interests in biological regulatory mechanisms. His current research is focussed on a theory he has developed on the cause (etiology) of chronic fatigue syndrome and the overlapping and related conditions of multiple chemical sensitivity, fibromyalgia, and post-traumatic stress disorder. Cases of each of these are initiated by short-term stressors that can increase nitric oxide which acts through it oxidant product peroxynitrite to initiate a biochemical vicious cycle known as the NO/ONOO- cycle which is responsible for producing chronic disease and for generating the symptoms and signs of illness. The local nature of the cycle, means that its localization to different tissues in different individuals can produce much variation in symptoms and signs among individuals. Many other chronic inflammatory diseases may be caused by this mechanism depending on the tissues impacted and other factors. The complexity of the cycle makes it a challenge to down-regulate but complex treatment protocols using multiple agents are the most promising approaches. The NO/ONOO- cycle theory has created much interest in the international biomedical community and has been recently presented in many national and international meetings.

Research Main
Chronic Fatigue Syndrome
Fibromyalgia, Excessive Nitric Oxide/Peroxynitrite and Excessive NMDA Activity
Multiple Chemical Sensitivity

Publications
Pall M. L., 2002. The levels of the nitric oxide synthase product, citrulline, are elevated in sera of chronic fatigue syndrome patients. J Chronic Fatigue Syndr 10(3/4):37-41.

Pall M. L., 2002. NMDA sensitization and stimulation by peroxynitrite, nitric oxide and organic solvents as the mechanism of chemical sensitivity in multiple chemical sensitivity. FASEB J 16:1407-1417.

Pall M. L. 2002. Chronic fatigue syndrome/myalgic encephalitis. Br J Gen Pract 52:762.

Smirnova I.V., Pall M.L. 2003. Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients. Mol Cell Biochem 248:93-95.

Pall M. L. 2003. Elevated nitric oxide/peroxynitrite theory of multiple chemical sensitivity: Central role of N-methyl-D-aspartate receptors in the sensitivity mechanism. Environ Health Perspect 111:1461-1464.

Pall M. L. 2004. Long delayed sequelae of organophosphate exposure. Arch Env Health 58:605.

Pall M. L. 2004. The simple truth about multiple chemical sensitivity. Environ Health Perspect 112:A266-A267.

Pall M. L., Anderson J. H. 2004 The vanilloid receptor as a putative target of diverse chemicals in multiple chemical sensivity. Arch Environ Health 59:1-13.

Pall M. L. 2005 Chronic fatigue syndrome and nitric oxide: giving credit where credit is due. Med Hypoth 65:631-633..

Pall M. L. 2005 Multiple chemical sensitivity: towards the end of controversy. Townsend Let Doctors Patients Aug/Sept 2005:52-56.

Pall M. L. 2006 The NO/ONOO- cycle as the cause of fibromyalgia and related illnesses: Etiology, explanation and effective therapy. In New Research in Fibromyalgia, John A. Pederson, ed. Nova Publishers, pp. 39-61.

Pall M. L. 2007 Explaining “Unexplained Illnesses”: Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress Disorder, Gulf War Syndrome and Others. 16 Chapter book, Haworth Medical Press.

Pall M. L. 2007 Nitric oxide synthase partial uncoupling as a key switching mechanism for the NO/ONOO- cycle. Med Hypoth Apr 18; [Epub ahead of print].