Kleinhofs, Andris
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Research Interests
The research in Andris Kleinhofs laboratory focuses on cloning and studying disease resistance genes and their function. Two barley stem rust resistance genes have been cloned and we are analyzing how they are expressed at the mRNA and protein level and how the proteins interact with the pathogen avirulence factors and cellular proteins to confer resistance. Research with disease resistance genes provides knowledge that can be used to design improved ways of protecting crops from pathogens.

Publications
Brueggeman, R., N. Rostoks, D. Kudrna, A. Kilian, F. Han, J. Chen, A. Druka, B. Steffenson, and A. Kleinhofs, 2002.  The barley stem rust-resistance gene Rpg1 is a novel disease-resistance gene with homology to receptor kinases.  Proc. Natl. Acad. Sci. USA 99:9328-9333.

Druka, A., D. Kudrna, C. G. Kannangara, D. von Wettstein, and A. Kleinhofs, 2002.  Physical and genetic mapping of barley (Hordeum vulgare) germin-like cDNAs.  Proc. Natl. Acad. Sci. USA 99:850-855.

Kleinhofs, A and A. Graner, 2002.  An integrated map of the barley genome.  In:  R. L. Phillips and I. Vasil, eds., DNA-Based Markers in Plants, 2nd Edition.  Kluwer Academic Publishers, Boston.  pp. 187-199.

Kleinhofs, A. and F. Han, 2002.  Molecular mapping of the barley genome.  In:  G. A. Slafer, J. L. Molini-Cano, R. Savin, J. L. Araus, I. Romagosa, eds., Barley Science, Recent Advances from Molecular Biology to Agronomy of Yield and Quality.  Food Products Press, New York.  pp. 31-45.

Rostoks, N., J. M. Zale, J. Soule, R. Brueggeman, A. Druka, D. Kudrna, B. Steffenson, and A. Kleinhofs, 2002.  A barley gene family homologous to the maize rust resistance gene Rp1-D.  Theor. Appl. Genet. 104:1298-1306.

Rostoks, N., Y.-J. Park, W. Ramakrishna, J. Ma, A. Druka, B. A. Shiloff, P. J. SanMiguel, Z. Jiang, R. Brueggeman, D. Sandhu, K. Gill, J. L. Bennetzen, and A. Kleinhofs, 2002.  Genomic sequencing reveals gene content, genomic organization, and recombination relationships in barley.  Functional and Integrative Genomics 2:51-59.

Vershinin, A. V., A. Druka, A. G. Alkhimova, A. Kleinhofs, and J. S. Heslop-Harrison, 2002.  LINEs and gypsy-like retrotransposons in Hordeum species.  Plant Mol. Biol. 49:1-14.

Castro, A. J., F. Capettini, A. E. Corey, T. Filichkina, P. M. Hayes, A. Kleinhofs, D. Kudrna, K. Richardson, S. Sandoval-Islas, C. Rossi, and H. Vivar, 2003.  Mapping and pyramiding of qualitative and quantitative resistance to stripe rust in barley.  Theor. Appl. Genet. 107:922-930. 

Druka, A., D. Kudrna, N. Rostoks, R. Brueggeman, D. von Wettstein, and A. Kleinhofs, 2003.  Chalcone isomerase gene from rice (Oryza sativa) and barley (Hordeum vulgare): physical, genetic and mutation mapping.  Gene 302:171-178.

Gao, W., J. A. Clancy, F. Han, D. Prada, A. Kleinhofs, and S. E. Ullrich, 2003.  Molecular dissection of a dormancy QTL region near the chromosome 7 (5H) L telomere in barley. Theor. Appl. Genet. 107:552-559.

Horvath, H., N. Rostoks, R. Brueggeman, B. Steffenson, D. von Wettstein, and A. Kleinhofs, 2003.  Genetically engineered stem rust resistance in barley using the Rpg1 gene.  Proc. Natl. Acad. Sci. USA 100:364-369.

Rostoks, N., D. Schmierer, D. Kudrna, and A. Kleinhofs, 2003.  Barley putative hypersensitive induced reaction genes: genetic mapping, sequence analyses and differential expression in disease lesion mimic mutants.  Theor. Appl. Genet. 107:1094-1101.

Bulgarelli, D., N. C. Collins, G. Tacconi, E. Dellaglio, R. Brueggeman, A. Kleinhofs, A. M. Stanca, and G. Vale, 2004.  High-resolution genetic mapping of the leaf stripe resistance gene Rdg2a in barley.  Theor. Appl. Genet. 108:1401-1408.

Close, T. J., S. Wanamaker, R. A. Caldo, S. M. Turner, D. A. Ashlock, J. A. Dickerson, R. A. Wing, G. J. Muehlbauer, A. Kleinhofs, and R. P. Wise, 2004.  A new resource for cereal genomics:  22K barley GeneChip comes of age.  Plant Physiol. 134:960-968.