Kang, Chul Hee
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Research Interests
Cancer-related Projects: Intensive efforts are taking place to determine the structures of various cancer-associated proteins and types of damaged DNA, including oxidative and UV damaged, and, ultimately, to develop anticancer drugs. Using complex crystal structures and binding studies, the search for new anti-cancer drugs that are free of side effects, are being carried out. We are also investigating key plant enzymes involved in various pathways, which have important and direct connections with human health such as chemoprotection against various cancers, lowering blood cholesterol levels, and as antifungal/antiviral agents, biocides, antifeedants, and antioxidants. These studies will be used to develop treatments for various cancers and for prevention of certain allergies.

Antibiotics-related Projects: One of major challenges for modern medical research is the development of new antibiotics against pathogenic bacteria. We are trying to identify candidates for new antibiotic targets, which is of immense importance for the development of new generation antibiotics.

Publications
Higgs,P., Letain,T.E. Merriam,K.K., Burke,N.S., Park,H., Kang,C., Postle,K. (2002) TonB Interacts with Non-receptor Proteins at the Outer Membrane of Escherichia coli J.Bacteriology. 184, 1640-1648.

MacLennan, D.H. and Kang,C. (2002) Structure-Function Relationships in Ca2+ Cycling proteins. Journal of Molecular and Cellular Cardiology. 34, 897-918.

Park,H-J., Suquet,C., Savenkova, M.I., Satterlee,J.D & Kang,C. (2002) Crystallization and Preliminary X-ray Analysis of the DOS Heme Domain: A new Heme Oxygen Sensor in E. coli. Acta Crystallographica D58, 1504-1506.

Park,H-J., Ren,Y, Sinha, N., Taylor, J-S. & Kang,C. (2002) Crystal Structure of a DNA Decamer Containing a Thymine-dimer. PNAS 99, 15965-15970.

Park, H-J., Wu, S., Dunker, A.K. & Kang, C. (2003) Polymerization of calsequestrin: Implications for Ca2+ regulation. J.Biol.Chem 278, 16176-16182.

Kang, C. (2003) Calsequestrin, Handbook of Metalloproteins series. Vol III, Wiley.

Min, T.-P., Kasahara, H., Bedgar, D.L., Hilsenbeck, J.L., Lawrence, P.K., Youn, B., Gang, D.R., Halls, S.C., Park, H.J., Davin, L.B., Lewis, N.G. & Kang, C.-H. (2003) Crystal structures of pinoresinol-lariciresinol and phenylcoumaran benzylic ether reductases, and their relationship to isoflavone reductases. J. Biol. Chem. 278, 50714-50723.

Kim, S-J., Kim, M-R, Bedgar, D.L., Moinuddin, S.G.A., Cardenas, C.L., Davin, L.B., Kang,C. & Lewis, N.G. (2003) Functional reclassification of the putative cinnamyl alcohol dehydrogenase (CAD) multigene family in Arabidopsis. PNAS, 1455-1460.

Ergenekan, K.E., Thomas, D., Fischer, J.T., Tan, M-L., Eidsness, M.K., Kang, C., & Ichiye, T. (2003) Prediction of reduction potential changes in rubredoxin: A molecular mechanics approach. Biophysical Journal 85, 2818-2829.

Hilsenbeck, J.L., Park, H-J., Chen, G., Youn, B., Postle, K. & Kang, C. (2004) Crystal structure of the cytotoxic bacterial protein Colicin B at 2.5 Å resolution. J. Molecular Microbiology 51, 711-720.

Park, H-J., Hilsenbeck, J.L., Kim, H.J., Shuttleworth, W.A., Evans, J.N. & Kang, C. (2004) Structural studies of Streptococcus pneumoniae EPSP synthase in unliganded state, tetrahedral intermediate bound state and S3P-GLP bound state. J. Molecular Microbiology 51, 963-971.

Park, I.Y., Youn, B., Harley, J.L., Eidness, M.K., Smith, E., Ichiye, T. & Kang, C (2004) The unique hydrogen bonded water in the reduced form of Clostridium pasteurianum rubredoxin and its possible role in electron transfer. J. Bio. Inor. Chem. 9, 423-428.

Venclovas, C., Ginalski, K. & Kang, C. (2004) Sequence-structure mapping errors in the PDB: OB-fold domains. Protein Science 13, 1594-1602.

Park, H-J., Suquet, C., Satterlee, J.D. & Kang, C. (2004) Insights into signal transduction involving PAS domain oxygen sensing heme proteins from the X-ray crystal structure of E. coli dos heme domain (EcDosH). Biochemistry 16, 2738-2746.

Park, H-J., Park, I-Y., Kim E.J., Wu, S., Youn, B., Fields, K., Dunker, A.K., & Kang, C. (2004) Comparing skeletal and cardiac calsequestrin structures and their calcium binding: a proposed mechanism for coupled calcium binding and protein polymerization. J. Biol. Chem. 279, 18026-18033.

Park, I-Y., Eidsness, M.K., Lin, I.J., Gebel, E.B., Youn, B., Harley, J.L., Machonkin, T.E., Frederick, R.O., Markley, J.L., Smith, E.T., Ichiye, T. & Kang, C. (2004) Crystallographic studies of V44 mutants of Clostridium pasteurianum rubredoxin: Effects of side chain size on reduction potential. PROTEINS: Structure, Function and Genetics 57, 618-624.

Kang,C. (2004) Calsequestrin, Handbook of Metalloproteins, Volume 3, Wiley.
Park, I-Y., Kim, E-J., Park, H.J., Fields, K., Dunker, K.A., & Kang, C. (2005) Interaction between cardiac calsequestrin and drugs with known cardiotoxicity. Mol. Pharmacology 67, 95-105.

Youn, B.H., Moinuddin, S.G.A., Davin, L.B., Lewis, N.G. & Kang, C. (2005) Crystal structures of apo-form, binary and ternary complexes of Podophyllum secoisolariciresinol dehydrogenase (SDH), an enzyme involved in formation of health-protecting lignans and in plant defense. J. Biol. Chem. 280, 12917-12926.

Tan, M-L., Kang, C., Ergenekan, C.E. & Ichiye, T. (2006) The role of backbone stability near Ala44 in the high reduction potential class of rubredoxins Proteins 62, 708-714.

Kim, E.J., Tam, M., Siems, W.F., & Kang, C. (2005) Effects of the drugs with muscle-related side effects and affinity to calsequestrin on the calcium regulatory function of SR microsomes. Mol. Pharmacology 68, 1708-1715.

Lee, S.M., Youn, B.H., Kim, C.S., Kim, J.S., Kang, C.H. & Kim, J. (2005) -Irradiation and doxorubicin in normal human cells show cell cycle arrest via different pathways. Mol. Cell 20, 331-338.

Moinuddin, S.G.A., Youn, B., Bedgar, D.A., Costa, M.A., Helms, G., Kang, C., Davin, L.B., & Lewis, N.G. (2006) Secoisolariciresinol dehydrogenase: mode of catalysis and stereospecificity of hydride transfer in Podophyllum peltatum. Org. Biomol. Chem. 4, 808-816.

Youn, B., Camacho, R., Moinuddin, S.G.A., Lee, C., Davin, L.B., Lewis, N.G. & Kang, C. (2006) Crystal structures and catalytic mechanisms of the Arabidopsis cinnamyl alcohol dehydrogenases AtCAD5 and AtCAD4. Org. Biomol. Chem. 4, 1687-1697.

Youn, B., Sellhorn, GE., Mirchel, RJ., Gaffney, BJ., Grimes, HD. & Kang, C. (2006) Crystal Structures of Vegetative Soybean Lipoxygenase VLX-B and VLX-D. Proteins 65, 1008-1020.

Youn B, Kim SJ, Moinuddin SG, Lee C, Bedgar DL, Harper AR, Davin LB, Lewis NG & Kang C. (2006) Mechanistic and structural studies of apoform, binary, and ternary complexes of the Arabidopsis alkenal double bond reductase at5g16970. J Biol Chem. 281, 40076-40088.

Hyatt DC, Youn, B, Zhao Y, Santhamma B, Coates RM, Croteau R. & Kang, C. (2007) Structure of limonene synthase, a simple model for terpenoid cyclase catalysis PNAS  104, 5360-5365.